Tools to therapeutically harness the human antibody response
نویسندگان
چکیده
منابع مشابه
Antibody Response to Human Extracellular HER2 Subdomain Proteins in Mice
Background: In addition to passive immunotherapy using anti-HER2 monoclonal antibodies, active immunotherapy via HER2 targeting is an interesting approach to inducing specific anti-tumor immune responses. We have recently reported the immunogenicity of HER2 subdomains following DNA immunization and HER2 protein boosting. In the present study, we evaluated the immunogenicity of different HER2 ex...
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H epatocellular carcinoma (HCC) is a common and highly lethal tumor that is currently the third-leading cause of cancer-related deaths (1). Hepatitis B virus (HBV) is responsible for more than 50% of HCC cases worldwide, making it the second most important known carcinogen for all types of cancer. Although prevention of HBV infection by implementation of universal infant vaccination strategies ...
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Objectives Natural humoral immune response and autoimmune mechanisms have great importance in keeping the balance of tumorimmunity, although it has not yet been fully understood. We aimed to reveal potential antitumor immune response by immunoglobulin (Ig) profile analysis of patients with metastatic melanomas. Methods A complex panel assay has been performed at expressed DNA and protein levels...
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BACKGROUND Vaccine-induced human antibodies to surface components of Haemophilus influenzae and Streptococcus pneumonia are correlated with protection. Monoclonal antibodies to surface components of Mycobacterium tuberculosis are also protective in animal models. We have characterized human antibodies that bind to the surface of live M. tuberculosis. METHODS Plasma from humans with latent tub...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2012
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri3285